FISH/CISH

In situ hybridisation (fluorescent for FISH and chromogenic for CISH) uses probes to analyse genetic changes (amplifications, deletions, translocations) in tumours. These probes are used to classify tumours (particularly in the case of lymphomas and soft tissue tumours) and identify prognostic factors or therapeutic targets for certain tumours (in the case of breast cancers or lung adenocarcinomas).

Material

Slides/blocks or cytological (including stained) preparations can be used.

 

Range

The following probes are available in our range:

 

Breast and stomach

  • HER2/CEN 17 amplification 17q12

 

Lung

  • ALK translocation, probe: BA, 2p23
  • ROS1 translocation, probe: BA, 6q22
  • RET translocation, probe: BA, 10q11
  • MET/CEP7 amplification 7q31/7p11.1

 

Lymphoma

  • MYC translocation, probe: BA, 8q24
  • BCL2 translocation, probe: BA, 18q21
  • BCL6 translocation, probe: BA, 3q27
  • CCND1 translocation, probe: BA, 11q13
  • MALT1 translocation, probe: BA, 18q21

 

Liposarcomas

  • MDM2/CEN 12 amplification 12q15

 

 

Your contact person

Head

PD Dr Davide Soldini

Specialist in Pathology and Molecular Pathology FMH

044 269 99 28

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